Skull Optical Clearing Kit

Use promptly after opening. Minor rod-shaped crystal precipitation at the bottom of Solution S3 is normal and does not affect product performance. For pigmented mice with intracranial blood vessels within the skull，partial thinning of the skull with a cranial drill is recommended prior to clearing for cortical observation; continue grinding until intracranial blood vessels are no longer visible. The skull optical clearing technique is a non-invasive cranial window clearing method. It greatly improves imaging depth and delivers a clean background after clearing to enhance imaging quality with ultra-fast processing，which takes only 15 minutes for full clearing. Its core advantage lies in regenerable skull bone after removing the clearing agent，enabling repeated in vivo imaging. Compatible with multiple optical detection systems including near-infrared imaging，laser speckle imaging，two-photon imaging，Raman imaging and fluorescence imaging，this product allows non-invasive high-definition visualization of subcutaneous，intracranial nerves，blood vessels and cells，effectively boosting the resolution and penetration depth of various in vivo optical imaging.