HMG-CoA Reductase (HGMR) Activity Assay Kit（Animal Sample）

3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase (HMGR;EC: 1.1.1.34),is a glycoprotein composed of 887 amino acid residues found in the endoplasmic reticulum of the liver,intestines, and other tissues. It is a rate-limiting enzyme in the synthesis of cholesterol in hepatocytes,catalyzing the formation of mevalonic acid,and inhibiting HMG-CoA reductase can hinder cholesterol synthesis. HMG-CoA consumes 2 molecules of NADPH to produce 3-methyl-3,5-dihydrolevalonic acid (mevalonic acid) and 2 molecules of NADP catalyzed by HMG-CoA, and the activity of HMGR enzyme is determined by measuring the change of absorbance value at 340nm.